Evidence for a negative Pasteur effect in articular cartilage
نویسندگان
چکیده
منابع مشابه
Evidence for a negative Pasteur effect in articular cartilage.
Uptake of external glucose and production of lactate were measured in freshly-excised bovine articular cartilage under O2 concentrations ranging from 21% (air) to zero (N2-bubbled). Anoxia (O2 concentration < 1% in the gas phase) severely inhibited both glucose uptake and lactate production. The decrease in lactate formation correlated closely with the decrease in glucose uptake, in a mole rati...
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It was suggested by Dingle (1962) that lysosomal enzymes might be responsible for damage to cartilage matrix in rheumatoid arthritis. Since then indirect evidence has linked Jysosomal hydrolases with tissue damage in this disease. For example, Fell and Dingle (1963) showed that cathepsin D could degrade the protein-polysaccharide complex of cartilage ground substance leading to loss of metachro...
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BACKGROUND Intra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s. PURPOSE To review the current literature on the effects of IA corticosteroids on articular cartilage. STUDY DESIGN Systematic review. METHODS A MEDLINE and SCOPUS database search was performed, and studies were selected for basic science and clinical...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1997
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3210095